RAPT Therapeutics Inc (NAS:RAPT)
$ 1.69 -0.12 (-6.63%) Market Cap: 63.27 Mil Enterprise Value: -32.31 Mil PE Ratio: 0 PB Ratio: 0.66 GF Score: 41/100
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Rapt Therapeutics Inc at Wells Fargo Virtual Healthcare Conference Transcript

Sep 09, 2021 / 12:00PM GMT
Release Date Price: $36.08 (+0.08%)
Brian Wong
RAPT Therapeutics - President & CEO

Apologize for the delay. Here we are on slide 8. This slide describes RPT193's novel upstream mechanism of action. For the interest of time, I'll just describe here that Th2 cells are known to drive allergic diseases by producing cytokines such as IL-4, IL-5, and IL-13 in the skin, which drive both thickening, inflammation, and itch.

The injectable biologics, such as Dupixent or dupilumab and the JAK inhibitors, act downstream of these cytokines. And in contrast, RPT193 acts upstream to these agents directly on Th2 cells. So when the skin is challenged, we can block the binding of the two ligands, CCL17 and CCL22, which are produced from binding to CCR4 and inhibit both the migration of these cells into the skin, as well as their functional capacity to produce IL-4, IL-5, and IL-13. So in essence, we cut off the -- not only cut off the supply of these cells into the skin, but also directly block their ability to produce these disease-causing cytokines.

And so this novel upstream mechanism of action, we think has several potential

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