Release Date: November 13, 2024
For the complete transcript of the earnings call, please refer to the full earnings call transcript.
Positive Points
- Mersana Therapeutics Inc (MRSN, Financial) made significant progress in their Phase I clinical trials for XMT-1660 and XMT-2056, with dose escalation ongoing and no maximum tolerated dose established yet.
- The company achieved multiple milestones in research collaborations and maintained a strong balance sheet, positioning them well for future developments.
- Mersana's proprietary Dolasynthen platform shows a differentiated tolerability profile, allowing higher dosing levels compared to previous ADCs.
- The company plans to disclose initial clinical data for XMT-1660 by the end of the year, which could highlight its potential across various tumor types.
- Mersana's financials show a significant reduction in net loss and operating expenses due to restructuring and collaboration payments, extending their cash runway into 2026.
Negative Points
- The company has not yet provided specific guidance on objective response rates (ORR) for their trials, making it difficult to benchmark against competitors.
- There is uncertainty regarding the optimal dosing schedule for XMT-1660, as more frequent dosing schedules are still under investigation.
- The heavily pretreated patient population in trials may present challenges in demonstrating efficacy, especially in those previously treated with TOPO1 ADCs.
- Mersana's focus on post-TOPO1 ADC patients may limit initial market opportunities, as TOPO1 ADCs are well-established in the current treatment landscape.
- The company faces competition from other B7-H4 ADCs, and differences in patient populations make direct comparisons challenging.
Q & A Highlights
Q: Since most patients enrolled are post-TOPO, how should we benchmark this versus other B7-H4 ADCs?
A: Martin Huber, President, CEO & Director: We're not providing specific guidance on ORR. We recognize other benchmarks, like Pfizer's 20% response rate, but there are nontrivial differences between populations. It's difficult to predict the right benchmark for us at this point.
Q: How many patients at efficacy evaluable dose are expected for the initial data update, and what percentage are biomarker positive?
A: Martin Huber, President, CEO & Director: We haven't provided that information yet. We'll share specifics on patient numbers and B7-H4 expression with the data later this year. We're enrolling all comers and looking at B7-H4 data retrospectively.
Q: Are you evaluating more frequent dosing schedules for XMT-1660, and how are they performing relative to the every four-week cohort?
A: Martin Huber, President, CEO & Director: We're not sharing details on dosing schedules yet. We have a core schedule of every four weeks and are exploring more frequent doses. We'll share data on dose correlation with activity when we release the data set.
Q: Can you provide additional color on Phase I patients' prior treatment history beyond TOPO ADC experience?
A: Martin Huber, President, CEO & Director: This is a heavily pretreated population. It's important to understand the nature of treatments, specifically prior ADC exposure. Investigators are seeking non-TOPO payloads, which is why we're seeing this patient population.
Q: How are you thinking about development in gynecological tumors?
A: Mohan Bala, Senior VP & Chief Development Officer: In endometrial cancer, there's a significant unmet need post-checkpoint inhibitor and chemotherapy. In ovarian cancer, there's a need for therapies that combine with platinum and continue treatment beyond platinum therapy.
For the complete transcript of the earnings call, please refer to the full earnings call transcript.
